InnateDB Protein
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IDBP-82318.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC39A7
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Protein Name
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solute carrier family 39 (zinc transporter), member 7
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Synonyms
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D6S115E; D6S2244E; H2-KE4; HKE4; KE4; RING5; ZIP7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363807
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InnateDB Gene
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IDBG-82314 (SLC39A7)
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Protein Structure
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Function |
Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). {ECO:0000269PubMed:14525538, ECO:0000269PubMed:15705588, ECO:0000269PubMed:22317921}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:14525538, ECO:0000269PubMed:15705588}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0046873
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metal ion transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002395
HMW kininogen
IPR003689
Zinc/iron permease
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PFAM |
PF02535
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PRINTS |
PR00334
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92504
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PhosphoSite |
PhosphoSite-Q92504
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TrEMBL |
Q29984
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UniProt Splice Variant |
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Entrez Gene |
7922
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UniGene |
Hs.631995
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RefSeq |
NP_001275706
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HUGO |
HGNC:4927
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OMIM |
601416
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CCDS |
CCDS43453
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HPRD |
09028
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IMGT |
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EMBL |
AF117221
AL031228
AL645940
AL662824
AL844527
BC000645
CH471081
CR354565
CR759733
CR759786
CR936877
D82060
M58660
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GenPept |
AAA63219
AAD12305
AAH00645
BAA11528
CAA20238
CAI17615
CAI18067
CAI41839
CAQ08249
CAQ09067
CAQ10301
CAQ11085
EAX03680
EAX03681
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