InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSD17B8

Summary

InnateDB Protein

IDBP-82361.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD17B8

Protein Name

hydroxysteroid (17-beta) dehydrogenase 8

Synonyms

D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363794

InnateDB Gene

IDBG-82359 (HSD17B8)

Protein Structure

UniProt Annotation

Function

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. {ECO:0000269PubMed:17978863, ECO:0000269PubMed:19571038}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:19571038}.

Disease Associations

Tissue Specificity

Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed. {ECO:0000269PubMed:17978863}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

SM00822

TIGRFAMs

Post-translational Modifications

Modification

Cross-References