Version 5.4
Homo sapiens Gene: HSD17B8
Summary
InnateDB Gene IDBG-82359.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B8
Gene Name hydroxysteroid (17-beta) dehydrogenase 8
Synonyms D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1
Species Homo sapiens
Ensembl Gene ENSG00000204228
Encoded Proteins
IDBP-82361
hydroxysteroid (17-beta) dehydrogenase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33204642-33206831
Strand Forward strand
Band p21.32
Transcripts
ENST00000374662 ENSP00000363794
ENST00000469186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0008152 metabolic process
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073422
View Gene Order
ENSBTAG00000020927
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q92506
TrEMBL
UniProt Splice Variant
Entrez Gene 7923
UniGene
RefSeq NM_014234
HUGO HGNC:3554
OMIM 601417
CCDS CCDS4769
HPRD
IMGT
EMBL AL031228 AL645940 AL662824 AL713971 AL844527 BC008185 BT007239 CH471081 CR759733 CR759786 CR847841 D82061
GenPept AAH08185 AAP35903 BAA11529 CAC38444 CAI17616 CAI17657 CAI18068 CAI41840 CAQ08245 CAQ10302 CAQ10313 EAX03682
RNA Seq Atlas 7923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca