InnateDB Protein
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IDBP-82424.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PMEPA1
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Protein Name
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prostate transmembrane protein, androgen induced 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344014
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InnateDB Gene
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IDBG-82420 (PMEPA1)
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Protein Structure
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Function |
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269PubMed:18703514, ECO:0000269PubMed:20129061, ECO:0000269PubMed:24627487}.
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Subcellular Localization |
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Highest expression in prostate. Also expressed in ovary.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0030512
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negative regulation of transforming growth factor beta receptor signaling pathway
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GO:0030521
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androgen receptor signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q969W9
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PhosphoSite |
PhosphoSite-Q969W9
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TrEMBL |
Q5JY37
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UniProt Splice Variant |
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Entrez Gene |
56937
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UniGene |
Hs.622471
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RefSeq |
NP_954638
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HUGO |
HGNC:14107
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OMIM |
606564
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CCDS |
CCDS13462
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HPRD |
09415
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IMGT |
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EMBL |
AF224278
AF305426
AF305616
AK296199
AL035541
AL121913
AY128643
BC015918
CH471077
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GenPept |
AAF86322
AAH15918
AAL09357
AAL16781
AAM89277
BAG58927
CAI19031
CAI23105
CAM27272
CAM28295
EAW75505
EAW75506
EAW75508
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