Version 5.4
Homo sapiens Gene: PMEPA1
Summary
InnateDB Gene IDBG-82420.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMEPA1
Gene Name prostate transmembrane protein, androgen induced 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124225
Encoded Proteins
IDBP-82422
prostate transmembrane protein, androgen induced 1
IDBP-82424
prostate transmembrane protein, androgen induced 1
IDBP-82426
prostate transmembrane protein, androgen induced 1
IDBP-238782
prostate transmembrane protein, androgen induced 1
IDBP-238784
prostate transmembrane protein, androgen induced 1
IDBP-238786
prostate transmembrane protein, androgen induced 1
IDBP-379318
prostate transmembrane protein, androgen induced 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:57648392-57711536
Strand Reverse strand
Band q13.31
Transcripts
ENST00000265626 ENSP00000265626
ENST00000347215 ENSP00000344014
ENST00000341744 ENSP00000345826
ENST00000395819 ENSP00000379164
ENST00000395816 ENSP00000379161
ENST00000395814 ENSP00000379159
ENST00000414037 ENSP00000401506
ENST00000472841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0050699 WW domain binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038400
View Gene Order
ENSBTAG00000031524
Not yet available
Pathways
NETPATH
REACTOME
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517155 Hs.611389 Hs.622471
RefSeq NM_001255976 NM_020182 NM_199169 NM_199170 NM_199171
HUGO
OMIM
CCDS CCDS13462 CCDS13463 CCDS13464
HPRD 09415
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca