Version 5.4
Homo sapiens Protein: PMEPA1
Summary
InnateDB Protein IDBP-82426.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMEPA1
Protein Name prostate transmembrane protein, androgen induced 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000345826
InnateDB Gene IDBG-82420 (PMEPA1)
Protein Structure
UniProt Annotation
Function Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269PubMed:18703514, ECO:0000269PubMed:20129061, ECO:0000269PubMed:24627487}.
Subcellular Localization Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity Highest expression in prostate. Also expressed in ovary.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0050699 WW domain binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969W9
PhosphoSite PhosphoSite-Q969W9
TrEMBL
UniProt Splice Variant
Entrez Gene 56937
UniGene Hs.622471
RefSeq NP_064567
HUGO HGNC:14107
OMIM 606564
CCDS CCDS13463
HPRD 09415
IMGT
EMBL AF224278 AF305426 AF305616 AL035541 AL121913 AY128643 BC015918 CH471077
GenPept AAF86322 AAH15918 AAL09357 AAL16781 AAM89277 CAI19031 CAI23105 CAM27272 CAM28295 EAW75505 EAW75508

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca