InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IDE

Summary

InnateDB Protein

IDBP-82460.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDE

Protein Name

insulin-degrading enzyme

Synonyms

INSULYSIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000360637

InnateDB Gene

IDBG-82456 (IDE)

Protein Structure

UniProt Annotation

Function

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269PubMed:10684867, ECO:0000269PubMed:17613531, ECO:0000269PubMed:18986166}.

Subcellular Localization

Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003824	catalytic activity
GO:0004222	metalloendopeptidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0042277	peptide binding
GO:0042803	protein homodimerization activity
GO:0043130	ubiquitin binding
GO:0043559	insulin binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0008286	insulin receptor signaling pathway
GO:0008340	determination of adult lifespan
GO:0010815	bradykinin catabolic process
GO:0010992	ubiquitin homeostasis
GO:0016032	viral process
GO:0032461	positive regulation of protein oligomerization
GO:0050435	beta-amyloid metabolic process
GO:0051260	protein homooligomerization
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:1901142	insulin metabolic process
GO:1901143	insulin catabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface