Version 5.4
Homo sapiens Protein: PFDN6
Summary
InnateDB Protein IDBP-82534.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN6
Protein Name prefoldin subunit 6
Synonyms H2-KE2; HKE2; KE-2; PFD6;
Species Homo sapiens
Ensembl Protein ENSP00000363734
InnateDB Gene IDBG-82528 (PFDN6)
Protein Structure
UniProt Annotation
Function Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269PubMed:9630229}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 29 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0016272 prefoldin complex
Protein Structure and Domains
PDB ID
InterPro IPR002777 Prefoldin beta-like
IPR009053 Prefoldin
PFAM PF01920
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15212
PhosphoSite PhosphoSite-O15212
TrEMBL Q5STK2
UniProt Splice Variant
Entrez Gene 10471
UniGene
RefSeq NP_001172110
HUGO HGNC:4926
OMIM 605660
CCDS CCDS4773
HPRD 16135
IMGT
EMBL AK312150 BC039033 BC059783 CH471081 Z97184
GenPept AAH39033 AAH59783 BAG35084 CAB09993 EAX03706 EAX03707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca