Version 5.4
Homo sapiens Gene: PFDN6
Summary
InnateDB Gene IDBG-82528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN6
Gene Name prefoldin subunit 6
Synonyms H2-KE2; HKE2; KE-2; PFD6
Species Homo sapiens
Ensembl Gene ENSG00000204220
Encoded Proteins
IDBP-82530
prefoldin subunit 6
IDBP-82532
prefoldin subunit 6
IDBP-82534
prefoldin subunit 6
IDBP-240181
prefoldin subunit 6
IDBP-473525
prefoldin subunit 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33289302-33298401
Strand Forward strand
Band p21.32
Transcripts
ENST00000374610 ENSP00000363738
ENST00000374607 ENSP00000363735
ENST00000374606 ENSP00000363734
ENST00000395134
ENST00000395131 ENSP00000378563
ENST00000491382
ENST00000463584 ENSP00000420135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 29 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0016272 prefoldin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024309
View Gene Order
ENSBTAG00000010723
Not yet available
Pathways
NETPATH
REACTOME
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001185181 NM_001265595 NM_001265596 NM_014260
HUGO
OMIM
CCDS CCDS4773
HPRD 16135
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca