InnateDB Protein
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IDBP-82569.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MFF
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Protein Name
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mitochondrial fission factor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000338412
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InnateDB Gene
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IDBG-82567 (MFF)
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Protein Structure
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Function |
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. {ECO:0000269PubMed:18353969, ECO:0000269PubMed:23530241}.
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Subcellular Localization |
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart, kidney, liver, brain, muscle, and stomach. {ECO:0000269PubMed:18353969}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008518
FATE/Miff/Tango-11
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PFAM |
PF05644
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9GZY8
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PhosphoSite |
PhosphoSite-Q9GZY8
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TrEMBL |
E9PPR7
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UniProt Splice Variant |
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Entrez Gene |
56947
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UniGene |
Hs.730366
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RefSeq |
NP_001263992
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HUGO |
HGNC:24858
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OMIM |
614785
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CCDS |
CCDS63139
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HPRD |
16653
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IMGT |
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EMBL |
AC097662
AF226049
AF246239
AF258660
AK026137
AL833032
BC000797
BC093024
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GenPept |
AAF86949
AAG44486
AAG44658
AAH00797
AAH93024
AAY24252
BAB15373
CAH56328
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