Version 5.4
Homo sapiens Protein: MSLN
Summary
InnateDB Protein IDBP-8272.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSLN
Protein Name mesothelin
Synonyms MPF; SMRP;
Species Homo sapiens
Ensembl Protein ENSP00000372313
InnateDB Gene IDBG-8270 (MSLN)
Protein Structure
UniProt Annotation
Function Membrane-anchored forms may play a role in cellular adhesion.Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.Megakaryocyte-potentiating factor: Secreted.Isoform 3: Secreted.
Disease Associations Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. {ECO:0000269PubMed:15897581}.
Tissue Specificity Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). {ECO:0000269PubMed:16857795, ECO:0000269PubMed:7665620}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0031016 pancreas development
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR010335 Mesothelin
PFAM PF06060
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13421
PhosphoSite PhosphoSite-Q13421
TrEMBL H3BV92
UniProt Splice Variant
Entrez Gene 10232
UniGene Hs.408488
RefSeq NP_037536
HUGO HGNC:7371
OMIM 601051
CCDS CCDS32356
HPRD 03030
IMGT
EMBL AE006464 AF180951 AL031258 AY743922 BC003512 BC009272 CH471112 D49441 U40434
GenPept AAC50348 AAF01409 AAH03512 AAH09272 AAK61253 AAV87530 BAA08419 CAC37289 EAW85719 EAW85720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca