InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDK5RAP2

Summary

InnateDB Protein

IDBP-82893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK5RAP2

Protein Name

CDK5 regulatory subunit associated protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343818

InnateDB Gene

IDBG-82889 (CDK5RAP2)

Protein Structure

UniProt Annotation

Function

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. {ECO:0000250, ECO:0000269PubMed:17959831, ECO:0000269PubMed:18042621, ECO:0000269PubMed:19282672, ECO:0000269PubMed:19553473}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends.

Disease Associations

Microcephaly 3, primary, autosomal recessive (MCPH3) [MIM:604804]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. {ECO:0000269PubMed:15793586}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:10721722}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000132	establishment of mitotic spindle orientation
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001578	microtubule bundle formation
GO:0007059	chromosome segregation
GO:0007420	brain development
GO:0022008	neurogenesis
GO:0045664	regulation of neuron differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046600	negative regulation of centriole replication
GO:0051297	centrosome organization
GO:0090231	regulation of spindle checkpoint

Cellular Component

GO:0000242	pericentriolar material
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome