InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSR1

Summary

InnateDB Protein

IDBP-8291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSR1

Protein Name

macrophage scavenger receptor 1

Synonyms

CD204; phSR1; phSR2; SCARA1; SR-A; SRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000262101

InnateDB Gene

IDBG-8289 (MSR1)

Protein Structure

UniProt Annotation

Function

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269PubMed:12244320}. Note=The disease may be caused by mutations affecting the gene represented in this entry. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families.Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269PubMed:21791690}. Note=The disease may be caused by mutations affecting the gene represented in this entry. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility.

Tissue Specificity

Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. {ECO:0000269PubMed:9548586}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010886	positive regulation of cholesterol storage
GO:0030301	cholesterol transport
GO:0034381	plasma lipoprotein particle clearance
GO:0042953	lipoprotein transport
GO:0045087	innate immune response (InnateDB)
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005581	collagen trimer
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030666	endocytic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0034362	low-density lipoprotein particle

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR003543 Macrophage scavenger receptor
IPR008160 Collagen triple helix repeat
IPR015988 STAT transcription factor, coiled coil
IPR017448 SRCR-like domain

PFAM

PF00530
PF03523
PF01391

PRINTS

PR00258
PR01408

PIRSF

SMART

SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt