Version 5.4
Homo sapiens Protein: CYP2C18
Summary
InnateDB Protein IDBP-83208.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2C18
Protein Name cytochrome P450, family 2, subfamily C, polypeptide 18
Synonyms CPCI; CYP2C; CYP2C17; P450-6B/29C; P450IIC17;
Species Homo sapiens
Ensembl Protein ENSP00000341293
InnateDB Gene IDBG-83204 (CYP2C18)
Protein Structure
UniProt Annotation
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00359
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P33260
PhosphoSite PhosphoSite-P33260
TrEMBL Q16750
UniProt Splice Variant
Entrez Gene 1562
UniGene Hs.694505
RefSeq NP_001122397
HUGO HGNC:2620
OMIM 601131
CCDS CCDS44460
HPRD 03085
IMGT
EMBL AK313403 AL583836 BC069666 BC096257 BC096258 BC096260 CH471066 L16869 L16870 L16871 L16872 L16873 L16874 L16875 L16876 M61853 M61856 X56452
GenPept AAA02630 AAB59356 AAH69666 AAH96257 AAH96258 AAH96260 BAG36199 CAA39833 CAH74067 EAW50024

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca