Version 5.4
Homo sapiens Protein: CNTRL
Summary
InnateDB Protein IDBP-83232.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTRL
Protein Name centriolin
Synonyms bA165P4.1; CEP1; CEP110; FAN;
Species Homo sapiens
Ensembl Protein ENSP00000362962
InnateDB Gene IDBG-83228 (CNTRL)
Protein Structure
UniProt Annotation
Function Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle- mediated abscission. {ECO:0000269PubMed:12732615, ECO:0000269PubMed:16213214}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10688839, ECO:0000269PubMed:11956314, ECO:0000269PubMed:12732615}. Note=During cytokinesis, localizes to a ring-like structure at the central midbody.
Disease Associations Note=A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
Tissue Specificity Highly expressed in testis and trachea. {ECO:0000269PubMed:10688839}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR009053 Prefoldin
IPR010978 tRNA-binding arm
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z7A1
PhosphoSite PhosphoSite-Q7Z7A1
TrEMBL Q5JVD6
UniProt Splice Variant
Entrez Gene 11064
UniGene Hs.653263
RefSeq XP_005251736
HUGO HGNC:1858
OMIM 605496
CCDS CCDS35118
HPRD 05691
IMGT
EMBL AC006430 AF083322 AF513978 AK074079 AL137068 AY651261 BC002932 BC089415 BC137286 BX640927
GenPept AAC32373 AAH02932 AAH89415 AAI37287 AAP43846 AAX35689 BAB84905 CAE45965 CAI12358 CAM13285

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca