Version 5.4
Homo sapiens Gene: CNTRL
Summary
InnateDB Gene IDBG-83228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTRL
Gene Name centriolin
Synonyms bA165P4.1; CEP1; CEP110; FAN
Species Homo sapiens
Ensembl Gene ENSG00000119397
Encoded Proteins
IDBP-83230
centriolin
IDBP-83232
centriolin
IDBP-83234
centriolin
IDBP-83238
centriolin
IDBP-83240
centriolin
IDBP-83244
centriolin
IDBP-379396
centriolin
IDBP-811395
centriolin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:121074863-121177610
Strand Forward strand
Band q33.2
Transcripts
ENST00000373865 ENSP00000362972
ENST00000373855 ENSP00000362962
ENST00000238341 ENSP00000238341
ENST00000373851
ENST00000373850 ENSP00000362956
ENST00000373847 ENSP00000362953
ENST00000373845
ENST00000373844 ENSP00000362950
ENST00000431571 ENSP00000413014
ENST00000468952
ENST00000491018
ENST00000613863 ENSP00000481072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057110
View Gene Order
ENSBTAG00000011417
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.607417 Hs.653263
RefSeq NM_007018 XM_005251679 XM_006716944
HUGO
OMIM
CCDS CCDS35118
HPRD 05691
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca