Version 5.4
Homo sapiens Protein: LEMD2
Summary
InnateDB Protein IDBP-83259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEMD2
Protein Name LEM domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000293760
InnateDB Gene IDBG-83257 (LEMD2)
Protein Structure
UniProt Annotation
Function Involved in nuclear structure organization. {ECO:0000269PubMed:16339967}.
Subcellular Localization Nucleus inner membrane {ECO:0000269PubMed:16339967}; Multi-pass membrane protein {ECO:0000269PubMed:16339967}. Note=Lamina-associated protein residing in the inner nuclear membrane (INM). Localized exclusively to the nuclear envelope, giving rise to a typical rim- like staining of the nuclear periphery.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:16339967}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0035914 skeletal muscle cell differentiation
GO:0043409 negative regulation of MAPK cascade
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0016020 membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR003887 LEM domain
IPR011015 LEM/LEM-like domain
IPR018996 Inner nuclear membrane protein MAN1
PFAM PF03020
PF09402
PRINTS
PIRSF
SMART SM00540
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NC56
PhosphoSite PhosphoSite-Q8NC56
TrEMBL D6RBV0
UniProt Splice Variant
Entrez Gene 221496
UniGene Hs.444845
RefSeq NP_851853
HUGO HGNC:21244
OMIM
CCDS CCDS4785
HPRD 13984
IMGT
EMBL AK074959 AK301083 AL158049 BC051803 CH471081
GenPept AAH51803 BAC11316 BAG62687 CAI21527 CAI21529 EAX03750 EAX03751

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca