InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NGEF

Summary

InnateDB Protein

IDBP-83403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NGEF

Protein Name

neuronal guanine nucleotide exchange factor

Synonyms

ARHGEF27; EPHEXIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000362653

InnateDB Gene

IDBG-83399 (NGEF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048013	ephrin receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0061002	negative regulation of dendritic spine morphogenesis
GO:0097190	apoptotic signaling pathway