InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TXNDC2

Summary

InnateDB Protein

IDBP-835.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXNDC2

Protein Name

thioredoxin domain containing 2 (spermatozoa)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000350419

InnateDB Gene

IDBG-833 (TXNDC2)

Protein Structure

UniProt Annotation

Function

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11399755}. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.

Disease Associations

Tissue Specificity

Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids. {ECO:0000269PubMed:11399755}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0045735	nutrient reservoir activity

Biological Process

GO:0006662	glycerol ether metabolic process
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process