Version 5.4
Homo sapiens Protein: UGT1A6
Summary
InnateDB Protein IDBP-83560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT1A6
Protein Name UDP glucuronosyltransferase 1 family, polypeptide A6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000303174
InnateDB Gene IDBG-83534 (UGT1A6)
Protein Structure
UniProt Annotation
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.
Subcellular Localization Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine. {ECO:0000269PubMed:1339448, ECO:0000269PubMed:18004212}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0019899 enzyme binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0030259 lipid glycosylation
GO:0044281 small molecule metabolic process
GO:0052695 cellular glucuronidation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
IPR007235 Glycosyl transferase, family 28, C-terminal
PFAM PF00201
PF04101
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19224
PhosphoSite PhosphoSite-P19224
TrEMBL Q5DSZ8
UniProt Splice Variant
Entrez Gene 54578
UniGene Hs.662354
RefSeq NP_001063
HUGO HGNC:12538
OMIM 606431
CCDS CCDS2507
HPRD 07071
IMGT
EMBL AC006985 AC114812 AF014112 AF297093 AY435141 BM924331 CH471063 DQ364250 J04093 M84122 M84123 M84124 M84130
GenPept AAA61247 AAA61251 AAB87411 AAC41717 AAG30420 AAR95642 ABC96774 EAW71055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca