InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UGT1A6

Summary

InnateDB Gene

IDBG-83534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT1A6

Gene Name

UDP glucuronosyltransferase 1 family, polypeptide A6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000167165

Encoded Proteins

IDBP-83554

UDP glucuronosyltransferase 1 family, polypeptide A6

IDBP-83560

UDP glucuronosyltransferase 1 family, polypeptide A6

IDBP-292883

UDP glucuronosyltransferase 1 family, polypeptide A6

IDBP-389397

UDP glucuronosyltransferase 1 family, polypeptide A6

IDBP-389399

UDP glucuronosyltransferase 1 family, polypeptide A6

IDBP-485190

UDP glucuronosyltransferase 1 family, polypeptide A6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:233691607-233773300

Strand

Forward strand

Band

q37.1

Transcripts

ENST00000373424	ENSP00000362523
ENST00000305139	ENSP00000303174
ENST00000406651	ENSP00000386107
ENST00000446481	ENSP00000401541
ENST00000441351	ENSP00000389637
ENST00000480628
ENST00000484784	ENSP00000419780
ENST00000478062

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0030259	lipid glycosylation
GO:0044281	small molecule metabolic process
GO:0052695	cellular glucuronidation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000054545

View Gene Order

Pathways

NETPATH

REACTOME

REACT_6784

Glucuronidation pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00830

Retinol metabolism pathway

hsa00040

Pentose and glucuronate interconversions pathway

hsa00500

Starch and sucrose metabolism pathway

hsa00140

Steroid hormone biosynthesis pathway

hsa00053

Ascorbate and aldarate metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00860

Porphyrin and chlorophyll metabolism pathway

hsa00982

Drug metabolism pathway

hsa00983

Drug metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.643992 Hs.662316 Hs.662354

RefSeq

NM_001072 NM_205862

HUGO

OMIM

CCDS

CCDS2507 CCDS2508

HPRD

07071

IMGT

EMBL

GenPept

RNA Seq Atlas