InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGRMC1

Summary

InnateDB Protein

IDBP-83591.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGRMC1

Protein Name

progesterone receptor membrane component 1

Synonyms

HPR6.6; MPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000217971

InnateDB Gene

IDBG-83589 (PGRMC1)

Protein Structure

UniProt Annotation

Function

Receptor for progesterone. {ECO:0000250}.

Subcellular Localization

Microsome membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0020037	heme binding

Biological Process

GO:0007411

axon guidance

Cellular Component

GO:0005730	nucleolus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome