InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A5

Summary

InnateDB Protein

IDBP-83663.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A5

Protein Name

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

Synonyms

2F1; AAC2; ANT2; T2; T3;

Species

Homo sapiens

Ensembl Protein

ENSP00000360671

InnateDB Gene

IDBG-83661 (SLC25A5)

Protein Structure

UniProt Annotation

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000269PubMed:20797633}.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	120 [view]
Protein-Protein	119 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015207	adenine transmembrane transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006810	transport
GO:0007059	chromosome segregation
GO:0008284	positive regulation of cell proliferation
GO:0015853	adenine transport
GO:0016032	viral process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome
GO:0071817	MMXD complex

Protein Structure and Domains

PDB ID

InterPro

IPR002067 Mitochondrial carrier protein
IPR002113 Adenine nucleotide translocator 1
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PR00926
PR00927

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05141