InnateDB Protein
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IDBP-83840.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEPT6
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Protein Name
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septin 6
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Synonyms
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SEP2; SEPT2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353278
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InnateDB Gene
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IDBG-83838 (SEPT6)
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Protein Structure
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Function |
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. {ECO:0000269PubMed:17229681, ECO:0000269PubMed:17803907}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:15774761}. Cleavage furrow {ECO:0000269PubMed:15774761}. Midbody {ECO:0000269PubMed:15774761}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:15915442}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000038
Cell division protein GTP binding
IPR016491
Septin
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00735
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PRINTS |
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PIRSF |
PIRSF006698
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14141
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PhosphoSite |
PhosphoSite-Q14141
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TrEMBL |
Q541S4
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UniProt Splice Variant |
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Entrez Gene |
23157
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UniGene |
Hs.598119
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RefSeq |
NP_665799
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HUGO |
HGNC:15848
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OMIM |
300683
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CCDS |
CCDS14585
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HPRD |
06716
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IMGT |
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EMBL |
AC004913
AC005052
AF403058
AF403059
AF403060
AF403061
AF403062
AK299273
AL355348
AY005981
AY034177
BC009291
BC011922
BC036240
CH471161
D50918
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GenPept |
AAF97496
AAH09291
AAH11922
AAH36240
AAK61492
AAK98547
AAK98548
AAK98549
AAK98550
AAK98551
BAA09477
BAG61293
CAI41426
EAW89854
EAW89856
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