InnateDB Protein
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IDBP-83911.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DEF6
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Protein Name
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differentially expressed in FDCP 6 homolog (mouse)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000319831
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InnateDB Gene
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IDBG-83909 (DEF6)
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Protein Structure
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Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
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Disease Associations |
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Tissue Specificity |
Broadly expressed in the immune system and can be detected in T and B-cells. {ECO:0000269PubMed:12651066}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H4E7
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PhosphoSite |
PhosphoSite-Q9H4E7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
50619
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UniGene |
Hs.15476
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RefSeq |
NP_071330
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HUGO |
HGNC:2760
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OMIM |
610094
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CCDS |
CCDS4802
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HPRD |
10869
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IMGT |
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EMBL |
AJ276095
AY241694
Z97832
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GenPept |
AAO91767
CAC08450
CAI20190
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