Version 5.4
Homo sapiens Gene: DEF6
Summary
InnateDB Gene IDBG-83909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEF6
Gene Name differentially expressed in FDCP 6 homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000023892
Encoded Proteins
IDBP-83911
differentially expressed in FDCP 6 homolog (mouse)
IDBP-376372
differentially expressed in FDCP 6 homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:35297852-35321771
Strand Forward strand
Band p21.31
Transcripts
ENST00000316637 ENSP00000319831
ENST00000444278 ENSP00000415357
ENST00000468102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002257
View Gene Order
ENSBTAG00000025622
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.15476
RefSeq NM_022047
HUGO
OMIM
CCDS CCDS4802
HPRD 10869
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca