InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SS18L1

Summary

InnateDB Protein

IDBP-84023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SS18L1

Protein Name

synovial sarcoma translocation gene on chromosome 18-like 1

Synonyms

CREST; LP2261;

Species

Homo sapiens

Ensembl Protein

ENSP00000359885

InnateDB Gene

IDBG-84021 (SS18L1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGOL1 at kinetochore (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous; with lowest levels in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.