InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LCOR

Summary

InnateDB Protein

IDBP-84049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCOR

Protein Name

ligand dependent nuclear receptor corepressor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360138

InnateDB Gene

IDBG-84045 (LCOR)

Protein Structure

UniProt Annotation

Function

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269PubMed:12535528}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00320, ECO:0000269PubMed:12535528}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12535528}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter