Version 5.4
Homo sapiens Protein: TRMT5
Summary
InnateDB Protein IDBP-8405.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRMT5
Protein Name TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261249
InnateDB Gene IDBG-8403 (TRMT5)
Protein Structure
UniProt Annotation
Function Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization Mitochondrion matrix {ECO:0000255HAMAP- Rule:MF_03152}. Nucleus {ECO:0000255HAMAP-Rule:MF_03152}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03152}. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255HAMAP- Rule:MF_03152}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016740 transferase activity
GO:0052906 tRNA (guanine(37)-N(1))-methyltransferase activity
Biological Process
GO:0030488 tRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR003402 tRNA transferase Trm5/Tyw2
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF02475
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32P41
PhosphoSite PhosphoSite-Q32P41
TrEMBL
UniProt Splice Variant
Entrez Gene 57570
UniGene Hs.380159
RefSeq NP_065861
HUGO HGNC:23141
OMIM 611023
CCDS CCDS32092
HPRD 17213
IMGT
EMBL AB037814 AK293158 AL160236 BC108284 BC136606 BC136607 CH471061
GenPept AAI08285 AAI36607 AAI36608 BAA92631 BAG56703 EAW80792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca