InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMF1

Summary

InnateDB Protein

IDBP-8417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMF1

Protein Name

lipase maturation factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262301

InnateDB Gene

IDBG-8415 (LMF1)

Protein Structure

UniProt Annotation

Function

Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19783858}; Multi-pass membrane protein {ECO:0000269PubMed:19783858}.

Disease Associations

Combined lipase deficiency (CLD) [MIM:246650]: Characterized by repeated episodes of pancreatitis, tuberous xanthomas and lipodystrophy and is caused by deficiency of both lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL). {ECO:0000269PubMed:17994020}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0009306	protein secretion
GO:0033578	protein glycosylation in Golgi
GO:0034382	chylomicron remnant clearance
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0051604	protein maturation
GO:0090181	regulation of cholesterol metabolic process
GO:0090207	regulation of triglyceride metabolic process