Version 5.4
Homo sapiens Protein: ARHGAP19
Summary
InnateDB Protein IDBP-84217.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP19
Protein Name Rho GTPase activating protein 19
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351333
InnateDB Gene IDBG-242852 (ARHGAP19)
Protein Structure
UniProt Annotation
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17454002}.
Disease Associations
Tissue Specificity Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary. {ECO:0000269PubMed:17454002}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PRINTS
PIRSF
SMART SM00324
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14CB8
PhosphoSite PhosphoSite-Q14CB8
TrEMBL Q8NA01
UniProt Splice Variant
Entrez Gene 84986
UniGene Hs.80305
RefSeq NP_116289
HUGO HGNC:23724
OMIM 611587
CCDS CCDS7454
HPRD 12475
IMGT
EMBL AK074122 AK090447 AK093316 AK093441 AK303055 AL359385 AY336750 BC113888 BC114490 CH471066 CR749412 DQ338460
GenPept AAI13889 AAI14491 AAR02412 ABC69298 BAB84948 BAC03428 BAC04130 BAC04165 BAG64173 CAH18254 CAI13728 CAI13731 EAW49952

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca