Version 5.4
Homo sapiens Gene: ARHGAP19
Summary
InnateDB Gene IDBG-242852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP19
Gene Name Rho GTPase activating protein 19
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213390
Encoded Proteins
IDBP-84217
Rho GTPase activating protein 19
IDBP-84219
Rho GTPase activating protein 19
IDBP-84225
Rho GTPase activating protein 19
IDBP-807495
Rho GTPase activating protein 19
IDBP-807329
ARHGAP19-SLIT1 readthrough (NMD candidate)
IDBP-807524
Rho GTPase activating protein 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:97222173-97292673
Strand Reverse strand
Band q24.1
Transcripts
ENST00000358531 ENSP00000351333
ENST00000358308 ENSP00000351058
ENST00000371027 ENSP00000360066
ENST00000492211 ENSP00000473327
ENST00000487035
ENST00000479633 ENSP00000473567
ENST00000466484 ENSP00000473667
ENST00000493068
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025154
View Gene Order
ENSBTAG00000040427
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q14CB8
TrEMBL Q8NA01
UniProt Splice Variant
Entrez Gene 84986
UniGene Hs.80305
RefSeq NM_001256423 NM_001204300 NM_032900
HUGO HGNC:23724
OMIM 611587
CCDS CCDS58092 CCDS73175 CCDS7454
HPRD 12475
IMGT
EMBL AK074122 AK090447 AK093316 AK093441 AK303055 AL359385 AY336750 BC113888 BC114490 CH471066 CR749412 DQ338460
GenPept AAI13889 AAI14491 AAR02412 ABC69298 BAB84948 BAC03428 BAC04130 BAC04165 BAG64173 CAH18254 CAI13728 CAI13731 EAW49952
RNA Seq Atlas 84986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca