InnateDB Protein
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IDBP-84225.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGAP19
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Protein Name
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Rho GTPase activating protein 19
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000360066
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InnateDB Gene
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IDBG-242852 (ARHGAP19)
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Protein Structure
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Function |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:17454002}.
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Disease Associations |
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Tissue Specificity |
Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary. {ECO:0000269PubMed:17454002}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0007165
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signal transduction
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GO:0007264
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small GTPase mediated signal transduction
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GO:0043547
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positive regulation of GTPase activity
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GO:0051056
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regulation of small GTPase mediated signal transduction
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Cellular Component |
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PDB ID |
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InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00620
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PRINTS |
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PIRSF |
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SMART |
SM00324
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TIGRFAMs |
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Modification |
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SwissProt |
Q14CB8
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PhosphoSite |
PhosphoSite-Q14CB8
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TrEMBL |
Q8NA01
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UniProt Splice Variant |
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Entrez Gene |
84986
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UniGene |
Hs.80305
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RefSeq |
NP_001243352
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HUGO |
HGNC:23724
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OMIM |
611587
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CCDS |
CCDS58092
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HPRD |
12475
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IMGT |
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EMBL |
AK074122
AK090447
AK093316
AK093441
AK303055
AL359385
AY336750
BC113888
BC114490
CH471066
CR749412
DQ338460
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GenPept |
AAI13889
AAI14491
AAR02412
ABC69298
BAB84948
BAC03428
BAC04130
BAC04165
BAG64173
CAH18254
CAI13728
CAI13731
EAW49952
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