InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAMP1

Summary

InnateDB Protein

IDBP-84369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAMP1

Protein Name

receptor (G protein-coupled) activity modifying protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000254661

InnateDB Gene

IDBG-84367 (RAMP1)

Protein Structure

UniProt Annotation

Function

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. {ECO:0000269PubMed:9620797}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract. {ECO:0000269PubMed:9620797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0015026	coreceptor activity
GO:0031716	calcitonin receptor binding

Biological Process

GO:0001525	angiogenesis
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0060050	positive regulation of protein glycosylation
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043235	receptor complex