InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAMP1

Summary

InnateDB Gene

IDBG-84367.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAMP1

Gene Name

receptor (G protein-coupled) activity modifying protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000132329

Encoded Proteins

IDBP-84369

receptor (G protein-coupled) activity modifying protein 1

IDBP-292862

receptor (G protein-coupled) activity modifying protein 1

IDBP-292833

receptor (G protein-coupled) activity modifying protein 1

IDBP-292835

receptor (G protein-coupled) activity modifying protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:237858893-237912114

Strand

Forward strand

Band

q37.3

Transcripts

ENST00000254661	ENSP00000254661
ENST00000404910	ENSP00000384688
ENST00000409726	ENSP00000386720
ENST00000403885	ENSP00000386046

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0015026	coreceptor activity
GO:0031716	calcitonin receptor binding

Biological Process

GO:0001525	angiogenesis
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0060050	positive regulation of protein glycosylation
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034353

View Gene Order

ENSBTAG00000011534

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_18290

Calcitonin-like ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04270

Vascular smooth muscle contraction pathway

INOH

PID NCI

Cross-References

SwissProt

O60894

TrEMBL

E9PC20 Q53SN3 Q53T50

UniProt Splice Variant

Entrez Gene

10267

UniGene

RefSeq

NM_005855

HUGO

HGNC:9843

OMIM

605153

CCDS

CCDS2522

HPRD

05515

IMGT

EMBL

AC012076 AC016776 AJ001014 AY265457 BC000548 CH471063 CR542032 CR542044

GenPept

AAH00548 AAP23298 AAY14674 AAY24219 CAA04472 CAG46829 CAG46841 EAW71127

RNA Seq Atlas

10267