Version 5.4
Homo sapiens Protein: ATP1B4
Summary
InnateDB Protein IDBP-84380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP1B4
Protein Name ATPase, Na+/K+ transporting, beta 4 polypeptide
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000218008
InnateDB Gene IDBG-84378 (ATP1B4)
Protein Structure
UniProt Annotation
Function May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. {ECO:0000269PubMed:17592128}.
Subcellular Localization Nucleus inner membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Detected in nuclear envelops. {ECO:0000269PubMed:14656723, ECO:0000269PubMed:17592128}.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle and at a lower level in heart. {ECO:0000269PubMed:10456317}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0015672 monovalent inorganic cation transport
Cellular Component
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005887 integral component of plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
Protein Structure and Domains
PDB ID
InterPro IPR000402 Sodium/potassium-transporting ATPase subunit beta
PFAM PF00287
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UN42
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 23439
UniGene Hs.292599
RefSeq NP_001135919
HUGO HGNC:808
OMIM
CCDS CCDS48158
HPRD 06453
IMGT
EMBL AF158383 AF158384 BC117227
GenPept AAD49692 AAD49693 AAI17228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca