Version 5.4
Homo sapiens Gene: ATP1B4
Summary
InnateDB Gene IDBG-84378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP1B4
Gene Name ATPase, Na+/K+ transporting, beta 4 polypeptide
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101892
Encoded Proteins
IDBP-84380
ATPase, Na+/K+ transporting, beta 4 polypeptide
IDBP-84382
ATPase, Na+/K+ transporting, beta 4 polypeptide
IDBP-597161
ATPase, Na+/K+ transporting, beta 4 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:120362085-120383249
Strand Forward strand
Band q24
Transcripts
ENST00000218008 ENSP00000218008
ENST00000361319 ENSP00000355346
ENST00000539306 ENSP00000443334
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0015672 monovalent inorganic cation transport
Cellular Component
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005887 integral component of plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016327
View Gene Order
ENSBTAG00000008920
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04260
Cardiac muscle contraction pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
hsa04974
Protein digestion and absorption pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B7ZKW0
UniProt Splice Variant
Entrez Gene 23439
UniGene Hs.292599
RefSeq NM_001142447 NM_012069
HUGO HGNC:808
OMIM
CCDS CCDS14598 CCDS48158
HPRD 06453
IMGT
EMBL AC006962 BC143407
GenPept AAI43408
RNA Seq Atlas 23439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca