InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMA5

Summary

InnateDB Protein

IDBP-84453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMA5

Protein Name

laminin, alpha 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000252999

InnateDB Gene

IDBG-84449 (LAMA5)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Tissue Specificity

Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005178	integrin binding
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001738	morphogenesis of a polarized epithelium
GO:0001755	neural crest cell migration
GO:0001942	hair follicle development
GO:0007010	cytoskeleton organization
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007517	muscle organ development
GO:0008037	cell recognition
GO:0008283	cell proliferation
GO:0009790	embryo development
GO:0009887	organ morphogenesis
GO:0016331	morphogenesis of embryonic epithelium
GO:0016477	cell migration
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030324	lung development
GO:0030334	regulation of cell migration
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042127	regulation of cell proliferation
GO:0042384	cilium assembly
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045446	endothelial cell differentiation
GO:0045995	regulation of embryonic development
GO:0048041	focal adhesion assembly
GO:0048754	branching morphogenesis of an epithelial tube
GO:0060445	branching involved in salivary gland morphogenesis
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005610	laminin-5 complex
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0031012	extracellular matrix
GO:0043259	laminin-10 complex
GO:0043260	laminin-11 complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000034 Laminin B type IV
IPR000742 Epidermal growth factor-like domain
IPR001368 TNFR/NGFR cysteine-rich region
IPR001791 Laminin G domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009254 Laminin I
IPR010307 Laminin domain II
IPR018031 Laminin B, subgroup

PFAM