Version 5.4
Homo sapiens Protein: ILKAP
Summary
InnateDB Protein IDBP-84483.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ILKAP
Protein Name integrin-linked kinase-associated serine/threonine phosphatase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254654
InnateDB Gene IDBG-84481 (ILKAP)
Protein Structure
UniProt Annotation
Function Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. {ECO:0000269PubMed:14990992}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11331582}.
Disease Associations
Tissue Specificity Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. {ECO:0000269PubMed:11331582}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0033262 regulation of nuclear cell cycle DNA replication
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like domain
PFAM PF00481
PF07228
PRINTS
PIRSF
SMART SM00331
SM00332
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0C8
PhosphoSite PhosphoSite-Q9H0C8
TrEMBL
UniProt Splice Variant
Entrez Gene 80895
UniGene Hs.92033
RefSeq NP_110395
HUGO HGNC:15566
OMIM
CCDS CCDS2526
HPRD 17147
IMGT
EMBL AC016757 AK001043 AL136850 AY024365 BC006576 CR533533
GenPept AAH06576 AAK07736 AAY24336 BAG50851 CAB66784 CAG38564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca