InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRB2

Summary

InnateDB Protein

IDBP-84574.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRB2

Protein Name

crumbs homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353092

InnateDB Gene

IDBG-84570 (CRB2)

Protein Structure

UniProt Annotation

Function

May play a role in polarized cells morphogenesis.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart. {ECO:0000269PubMed:15851977}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019828	aspartic-type endopeptidase inhibitor activity
GO:0019899	enzyme binding

Biological Process

GO:0001707	mesoderm formation
GO:0001756	somitogenesis
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010951	negative regulation of endopeptidase activity
GO:0014028	notochord formation
GO:0030513	positive regulation of BMP signaling pathway
GO:0045199	maintenance of epithelial cell apical/basal polarity
GO:0072358	cardiovascular system development

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF00054
PF02210
PF07645
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00210
SM00282
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5IJ48