Version 5.4
Homo sapiens Gene: CRB2
Summary
InnateDB Gene IDBG-84570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRB2
Gene Name crumbs homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148204
Encoded Proteins
IDBP-84572
crumbs homolog 2 (Drosophila)
IDBP-84574
crumbs homolog 2 (Drosophila)
IDBP-584837
crumbs homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:123356170-123380324
Strand Forward strand
Band q33.3
Transcripts
ENST00000373631 ENSP00000362734
ENST00000359999 ENSP00000353092
ENST00000460253 ENSP00000435279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0019899 enzyme binding
Biological Process
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010951 negative regulation of endopeptidase activity
GO:0014028 notochord formation
GO:0030513 positive regulation of BMP signaling pathway
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0072358 cardiovascular system development
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035403
View Gene Order
ENSBTAG00000014391
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.710092
RefSeq NM_173689 XM_005251934
HUGO
OMIM
CCDS CCDS6852
HPRD 13093
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca