InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DENND1A

Summary

InnateDB Protein

IDBP-84622.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DENND1A

Protein Name

DENN/MADD domain containing 1A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362727

InnateDB Gene

IDBG-84620 (DENND1A)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles. {ECO:0000269PubMed:20154091, ECO:0000269PubMed:20937701}.

Subcellular Localization

Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269PubMed:20937701}; Peripheral membrane protein {ECO:0000269PubMed:20937701}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:20937701}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017112	Rab guanyl-nucleotide exchange factor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006897	endocytosis
GO:0015031	protein transport
GO:0032483	regulation of Rab protein signal transduction
GO:0032851	positive regulation of Rab GTPase activity
GO:0048488	synaptic vesicle endocytosis

Cellular Component

GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030425	dendrite
GO:0030665	clathrin-coated vesicle membrane
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0045202	synapse