InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDF4

Summary

InnateDB Protein

IDBP-84650.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDF4

Protein Name

stromal cell derived factor 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263741

InnateDB Gene

IDBG-84646 (SDF4)

Protein Structure

UniProt Annotation

Function

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.

Subcellular Localization

Isoform 1: Golgi apparatus lumen {ECO:0000250}.Isoform 5: Cytoplasm. Cell projection, bleb. Note=Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 5 is expressed in pancreas. {ECO:0000269PubMed:17442889}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0009650	UV protection
GO:0017156	calcium ion-dependent exocytosis
GO:0021549	cerebellum development
GO:0045444	fat cell differentiation
GO:0045471	response to ethanol
GO:0070625	zymogen granule exocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032059	bleb
GO:0070062	extracellular vesicular exosome