InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGAM1

Summary

InnateDB Protein

IDBP-84721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGAM1

Protein Name

phosphoglycerate mutase 1 (brain)

Synonyms

HEL-S-35; PGAM-B; PGAMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000359991

InnateDB Gene

IDBG-84719 (PGAM1)

Protein Structure

UniProt Annotation

Function

Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.

Subcellular Localization

Disease Associations

Tissue Specificity

In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004082	bisphosphoglycerate mutase activity
GO:0004083	bisphosphoglycerate 2-phosphatase activity
GO:0004619	phosphoglycerate mutase activity
GO:0005515	protein binding
GO:0016868	intramolecular transferase activity, phosphotransferases
GO:0019901	protein kinase binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006110	regulation of glycolytic process
GO:0016311	dephosphorylation
GO:0043456	regulation of pentose-phosphate shunt
GO:0044281	small molecule metabolic process
GO:0045730	respiratory burst