InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPK13

Summary

InnateDB Protein

IDBP-84741.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK13

Protein Name

mitogen-activated protein kinase 13

Synonyms

MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4;

Species

Homo sapiens

Ensembl Protein

ENSP00000211287

InnateDB Gene

IDBG-84731 (MAPK13)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269PubMed:11500363, ECO:0000269PubMed:11943212, ECO:0000269PubMed:15632108, ECO:0000269PubMed:17256148, ECO:0000269PubMed:18006338, ECO:0000269PubMed:18367666, ECO:0000269PubMed:20478268, ECO:0000269PubMed:9731215}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. {ECO:0000269PubMed:10201954, ECO:0000269PubMed:9374491}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0006970	response to osmotic stress
GO:0007049	cell cycle
GO:0007265	Ras protein signal transduction
GO:0018105	peptidyl-serine phosphorylation
GO:0032755	positive regulation of interleukin-6 production
GO:0035556	intracellular signal transduction
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050729	positive regulation of inflammatory response

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008351 Mitogen-activated protein (MAP) kinase, JNK
IPR008352 Mitogen-activated protein (MAP) kinase, p38
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109
PR01772
PR01773

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt