InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAPK13

Summary

InnateDB Gene

IDBG-84731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK13

Gene Name

mitogen-activated protein kinase 13

Synonyms

MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4

Species

Homo sapiens

Ensembl Gene

ENSG00000156711

Encoded Proteins

IDBP-84739

mitogen-activated protein kinase 13

IDBP-84741

mitogen-activated protein kinase 13

IDBP-84745

mitogen-activated protein kinase 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:36127809-36144524

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000373766	ENSP00000362871
ENST00000211287	ENSP00000211287
ENST00000373759	ENSP00000362864
ENST00000476951
ENST00000490334

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0006970	response to osmotic stress
GO:0007049	cell cycle
GO:0007265	Ras protein signal transduction
GO:0018105	peptidyl-serine phosphorylation
GO:0032755	positive regulation of interleukin-6 production
GO:0035556	intracellular signal transduction
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050729	positive regulation of inflammatory response