InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR6A1

Summary

InnateDB Protein

IDBP-84874.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR6A1

Protein Name

nuclear receptor subfamily 6, group A, member 1

Synonyms

CT150; GCNF; GCNF1; hGCNF; hRTR; NR61; RTR;

Species

Homo sapiens

Ensembl Protein

ENSP00000341135

InnateDB Gene

IDBG-84872 (NR6A1)

Protein Structure

UniProt Annotation

Function

Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Shows highest expression in the germ cells of the adult testis. {ECO:0000269PubMed:8982251, ECO:0000269PubMed:9134503, ECO:0000269PubMed:9177477, ECO:0000269PubMed:9493564, ECO:0000269PubMed:9537518}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007276	gamete generation
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt