InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NR6A1

Summary

InnateDB Gene

IDBG-84872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR6A1

Gene Name

nuclear receptor subfamily 6, group A, member 1

Synonyms

CT150; GCNF; GCNF1; hGCNF; hRTR; NR61; RTR

Species

Homo sapiens

Ensembl Gene

ENSG00000148200

Encoded Proteins

IDBP-84874

nuclear receptor subfamily 6, group A, member 1

IDBP-84876

nuclear receptor subfamily 6, group A, member 1

IDBP-380079

nuclear receptor subfamily 6, group A, member 1

IDBP-483200

nuclear receptor subfamily 6, group A, member 1

IDBP-478591

nuclear receptor subfamily 6, group A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:124517275-124771310

Strand

Reverse strand

Band

q33.3

Transcripts

ENST00000344523	ENSP00000341135
ENST00000373584	ENSP00000362686
ENST00000416460	ENSP00000413701
ENST00000487099	ENSP00000420267
ENST00000475178	ENSP00000420587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007276	gamete generation
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000063972

View Gene Order

ENSBTAG00000040585

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.20131 Hs.586460 Hs.608560 Hs.628634

RefSeq

NM_001278546 NM_001489 NM_033334 XM_005251917 XM_005251918

HUGO

OMIM

CCDS

CCDS35137 CCDS55340 CCDS65127

HPRD

04147

IMGT

EMBL

GenPept

RNA Seq Atlas