InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ETV7

Summary

InnateDB Protein

IDBP-84886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETV7

Protein Name

ets variant 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341843

InnateDB Gene

IDBG-84882 (ETV7)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in hematopoietic tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0009887	organ morphogenesis
GO:0030154	cell differentiation