InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGXT

Summary

InnateDB Protein

IDBP-84954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGXT

Protein Name

alanine-glyoxylate aminotransferase

Synonyms

AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6;

Species

Homo sapiens

Ensembl Protein

ENSP00000302620

InnateDB Gene

IDBG-84952 (AGXT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Peroxisome. Mitochondrion matrix. Note=Except in some HP1 patients where AGT is found in the mitochondrial matrix.

Disease Associations

Hyperoxaluria primary 1 (HP1) [MIM:259900]: An inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and progressive tissue accumulation of insoluble calcium oxalate. Affected individuals are at risk for nephrolithiasis, nephrocalcinosis and early onset end-stage renal disease. {ECO:0000269PubMed:10394939, ECO:0000269PubMed:10453743, ECO:0000269PubMed:10541294, ECO:0000269PubMed:10862087, ECO:0000269PubMed:12559847, ECO:0000269PubMed:1301173, ECO:0000269PubMed:1349575, ECO:0000269PubMed:15253729, ECO:0000269PubMed:15849466, ECO:0000269PubMed:15961946, ECO:0000269PubMed:15963748, ECO:0000269PubMed:1703535, ECO:0000269PubMed:2039493, ECO:0000269PubMed:8101040, ECO:0000269PubMed:9192270, ECO:0000269PubMed:9604803}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004760	serine-pyruvate transaminase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008453	alanine-glyoxylate transaminase activity
GO:0008483	transaminase activity
GO:0016597	amino acid binding
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006625	protein targeting to peroxisome
GO:0008152	metabolic process
GO:0009436	glyoxylate catabolic process
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate
GO:0019448	L-cysteine catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042853	L-alanine catabolic process
GO:0042866	pyruvate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046487	glyoxylate metabolic process
GO:0046724	oxalic acid secretion
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP